What is the single, most frequent adverse event noted in clinical trials with testosterone and the primary dose-limiting adverse event with testosterone?

The problem with defining a number that denotes hypogonadism is the lack of standardization of different lab machines and fluctuating levels of testosterone throughout the day.

Melatonin is dosed based on titration to effect.

Medical studies demonstrate that melatonin decreases migraines, cluster headaches and HTN.

Oral estrogen has been associated with a prothrombotic effect that is greatest within the first year of use, then decreases over the next few years.

All women who have been on HRT for five years or more should stop HRT as recommended by the AMA and ACOG.

The thrombosis with estrogen is due to plaque destabilization as estrogen does not cause an increase in plaque formation.

In the WHI Trial, HRT caused an increase in breast CA by 26% and a reduction in colon CA by 27%.

Because of the misleading reports from the WHI, millions of HRT users have stopped estrogen despite the confirmed 34% decrease in hip fractures. This results in millions of hip fractures.

The only risk factor in the estrogen-only arm in the WHI Trial was an increase in CAD.

The WHI Trial observed a 105% increase in AD.

The incidence of mortality from hip fractures is ten times greater than that of breast cancer.